Regenerative Potential of Mesenchymal Stromal Cells: Age-Related Changes
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چکیده
منابع مشابه
Regenerative Potential of Mesenchymal Stromal Cells: Age-Related Changes
Preclinical and clinical studies have shown that a therapeutic effect results from mesenchymal stromal cells (MSCs) transplant. No systematic information is currently available regarding whether donor age modifies MSC regenerative potential on cutaneous wound healing. Here, we evaluate whether donor age influences this potential. Two different doses of bone marrow MSCs (BM-MSCs) from young, adu...
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Aging at the cellular level is a complex process resulting from accumulation of various damages leading to functional impairment and a reduced quality of life at the level of the organism. With a rise in the elderly population, the worldwide incidence of osteoporosis (OP) and osteoarthritis (OA) has increased in the past few decades. A decline in the number and "fitness" of mesenchymal stromal ...
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MSCs are widely applied to regenerate heart tissue in myocardial diseases but when grown in standard two-dimensional (2D) cultures exhibit limited potential for cardiac repair and develop fibrogenic features with increasing culture time. MSCs can undergo partial cardiomyogenic differentiation, which improves their cardiac repair capacity. When applied to collagen patches they may improve cardia...
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Extracellular vesicles (EVs) derived from human bone marrow mesenchymal stromal cells (MSCs) promote the regeneration of kidneys in different animal models of acute kidney injury (AKI) in a manner comparable with the cells of origin. However, due to the heterogeneity observed in the EVs isolated from MSCs, it is unclear which population is responsible for the proregenerative effects. We therefo...
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Mesenchymal stromal cells (MSCs) are multipotent somatic cells resident in many tissues and organs. They have specific characteristics that distinguish them from other cell types. They are self-renewing cells with multi-lineage differentiation potential. In addition, they possess anti-inflammatory and immunomodulatory properties. Studies have shown that they could be used as vehicles to deliver...
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ژورنال
عنوان ژورنال: Stem Cells International
سال: 2016
ISSN: 1687-966X,1687-9678
DOI: 10.1155/2016/1461648